Crime + investigation

Charles Cullen, Niels Högel and Others: Inside the Minds of Serial Killers Who Worked in Health Care

From German nurse Niels Högel to U.K. doctor Harold Shipman to American nurse Charles Cullen, some serial killers target their patients.

2003 Getty Images
Published: November 01, 2022Last Updated: July 16, 2026

In 2005, a colleague of German nurse Niels Högel caught him doing something horrific: injecting a hospital patient not with a life-saving drug, but with one that induced a fatal heart attack. From there, the horrors only escalated. After a decade-long investigation that involved exhuming more than 130 bodies, a German court convicted the 42-year-old caregiver of murdering 85 patients over five years. His motivation? A twisted desire to bring people to the brink of death and then earn praise by "heroically" resuscitating them.

Investigators suspect he may have committed as many as 300 such murders, which could make Högel the most prolific health care serial killer in history. But he's not alone in taking advantage of his caregiving position to gratify murderous urges.

In 2000, U.K. physician Harold Shipman was convicted of killing 15 patients by injecting lethal amounts of painkiller. (A government report later estimated his victim tally at closer to 250.) And American nurse Charles Cullen, who had a long history of mental instability, confessed to killing at least 40 patients over 16 years—mostly via lethal injections—while working in numerous New Jersey and Pennsylvania hospitals. Officials believe his murder count may also have reached into the hundreds.

Health care killings remain rare—research shows an estimated 35 a year across the U.S.—but exact numbers are hard to pin down since these crimes can be hard to detect in hospitals and nursing homes, where death is an everyday occurrence. Since 1970, there have been over 151 prosecutions of health care providers globally for the serial murder of patients, says Beatrice Yorker, professor emerita of nursing, criminal justice and criminalistics at California State University in Los Angeles and co-author of a 2006 study of medical serial killers.

While the numbers are still small, health care provider serial killings have "consistently trended up" until the 2010s Yorker tells A&E. (Five prosecutions in the 1970s, 16 in the '80s, 25 in the '90s and 60 in the 2000s.) "We believe that increased awareness, safeguards in hospitals and better tracking of medicines have contributed to a decrease—down to 28 prosecutions—in the 2010s," Yorker says.

Crime of Opportunity

One reason for the uptick is the relative ease with which these killings can be committed.

"In any given profession, there is a small percent of psychopaths," Yorker explains. "However, if you happen to be a psychopath and you're a nurse or a doctor, the opportunity is almost too easy… You don't have to be like Ted Bundy and organize your search of a victim, select instruments for abduction and killing, and be in the right place and be able to carve them up… It's some pretty heavy lifting to kill people out on the street."

By comparison, she says, it's much easier for a nurse to kill a patient they are assigned to care for who's receiving IV medications. According to her study, the vast majority (86 percent) of serial killings in medical settings globally are committed by nursing staff, not doctors.

Yorker's study also found that the plurality of these killers used lethal injection as their weapon of choice—in particular, injections of insulin, which at high doses can fatally lower the patient's blood sugar levels, sending them into hypoglycemic shock. Because a fatal insulin overdose can take hours to days to kill, the administering nurse is often off-shift when the victim flatlines. Lesser-used methods, according to the research, include suffocation, poisoning and equipment tampering.

Different countries operate their hospitals under different regulatory controls, which means that in some nations it's harder to kill patients by interfering with their intravenous fluids. In America, the FDA introduced mandatory barcode readings in 2004 on all drugs administered to patients at hospitals. That rule—designed as a safeguard against medication errors—also means that lethal doses of insulin and other dangerous drugs are harder to obtain and misuse and can be more easily traced to the perpetrator.

Since so much of health care serial killing boils down to ease of opportunity, American medical personnel intent on foul play have turned to other methods of murder. Since the 2004 FDA ruling, American hospital killings have trended toward the injection of bleach and air.

"What we're seeing in the United States are more creative methods," says Yorker. "The serial nurse killers have gone deeper underground. They're figuring out ways to avoid detection, even in our current system of tracking. For example, injecting air into an IV line does not raise red flags in a medication counting system."

Playing the Hero

It's hard to ascribe all health care serial killings to a single motive. Some perpetrators are thrill seekers excited by the transgressive act of killing. Others get a rush from "playing God," determining who lives and who dies.

Many, like Högel, hope to "play the hero." After inducing cardiac arrest in his patients, the German nurse would soak up the adulation when he successfully revived them, earning the nickname "Resuscitation Rambo" among his colleagues in the process. Those who died were collateral damage in his quest for affirmation.

Psychologists refer to this behavior—intentionally making a dependent sick in your care, in order to garner sympathy—as Munchausen syndrome by proxy (MSP). Most often, the perpetrator is a parent and the victim, their child.

Munchausen syndrome, where the person simply feigns illness themselves to draw sympathy, is more common. But there's also overlap between the two, and several murderous nurses have shown both behaviors. Over one four-year span, English nurse Beverley Allitt sought treatment 24 times for her own fake ailments; then, in 1993, she was convicted of killing four child patients.

Other medical serial killers have even more mystifying motives. In Japan, nurse Ayumi Kuboki killed as many as 20 elderly patients in her care by adding disinfectant to their IV bags. She told police she would add the poisoning agent to control the timing of the patients' death—specifically so they would die while she was off duty, sparing her the uncomfortable task of informing the families.

Many paint themselves as compassionate "angels" helping to end suffering. Cullen, the New Jersey nurse, claimed to have killed patients out of a sense of mercy—a difficult explanation to swallow, given that many of his victims weren't terminally ill.

"It's absolutely disingenuous," Yorker says. "If it was genuine, they would have been talking with the family [about options regarding pain management]. It would be a team meeting with informed consent (like Dr. Jack Kevorkian obtained)... When a nurse says, 'Oh, I was only trying to help,' that is a lie; often the murdered patients were not terminally ill. It is part of these killers' psychopathy."

A Womanly Type of Murder

Unlike other forms of homicide, serial murder by health care professionals nears gender parity. According to Yorker's research, in the last five decades 49 percent of health care serial killers were women. In a sense, "male nurses are overrepresented," Yorker says, because even though they make up over half of nurse serial killers they only make up about 13 percent of the nursing workforce.

By contrast, women only represent an estimated 7 percent of overall serial killers. In the context of serial killing, women are dramatically overrepresented among health care serial killers.

"There are a lot of women doing this… This is a feminine form of violence. As a society, we have laws and we recognize and put people in prison for bludgeoning, shooting, strangling, raping. Those are masculine forms of violence… We as a society are less familiar with feminine forms of violence: poisoning, suffocating, killing with kindness."

Related Features:

I Faced Richard Ramirez in Court: My Experience During the 'Night Stalker' Jury Selection

Jury selection was as tumultuous as his crimes were heinous.

6m read

Who Is Joel Rifkin? The Serial Killer Admitted to 17 Murders

He committed some of the killings in his mom's house on Long Island, N.Y.

7m read

Why ‘Son of Sam’ David Berkowitz Skipped His Last Parole Hearing

The serial killer was sentenced to 25 years to life in prison for six murders.

7m read

Monica White Dated 'Shopping Cart Killer' Anthony Robinson, Suspected of Killing 6 Women

Lifetime's 'The Dating App Killer' is based on her experience.

6m read

A Serial Killer Hid in Plain Sight While Working at a Hospital

Efren Saldivar was an RT convicted of murdering six patients.

6m read

Did Ted Bundy Carry Out the 1969 Garden State Parkway Murders?

Teen Susan Davis and Elizabeth Perry were killed outside Ocean City, N.J.

7m read

Could Ted Bundy Be Responsible for 4 Cold Cases in Utah? New DNA May Hold the Key

In 2026, DNA connected Bundy to the 1974 murder of teen Laura Ann Aime.

6m read

Who Was Robert Eugene Brashers, the Man Behind the Yogurt Shop Murders?

The murders remained unsolved until DNA revealed a serial killer.

7m read

Who Was the Atlanta Ripper?

An unidentified serial killer preyed on Black women during the 1910s.

5m read

Why Police Believe Serial Killer Billy Mansfield Had More Victims

Authorities looked for more remains in Florida in June 2026.

5m read

How Was Jeffrey Dahmer Caught?

Police arrested the serial killer on July 22, 1991.

6m read

Who Was the 'Sacramento Slayer'? All About Morris Solomon Jr.

The serial killer took his first known victim on June 18, 1986.

9m read

Before Dumping Victims at Gilgo Beach, Rex Heuermann Tortured Them in His Long Island Home

The "Long Island Serial Killer" pleaded guilty to seven murders.

6m read

How Rex Heuermann Was Arrested in Connection to the Gilgo Beach Murders

The man allegedly behind seven homicides was caught in 2023.

6m read

Why Would a Dad Kill 5 of His Infant Children?

Paul Allen Perez murdered and abused the newborns between 1992 and 2001.

6m read

Where Is Gary Ridgway Now? Inside the Green River Killer's Life in Prison

He has lived in isolation at Washington State Penitentiary since 2004.

7m read

Why Juan Corona Is One of America's Most Overlooked Serial Killers

He murdered 25 migrant workers between February and May 1971.

5m read

The Search for the Santa Rosa Hitchhiker Murderer Continues More Than 5 Decades Later

Seven girls and young women were murdered in California in the 1970s.

5m read

Was Herb Baumeister a Serial Killer Responsible for Murdering 25 Men in Indiana?

He died by suicide in July 1996 after police issued a warrant for his arrest.

7m read

Why ‘Fast Food Killer’ Paul Dennis Reid Stopped Fighting Death Sentence

Reid went on a murder spree in Tennessee over three months in 1997.

6m read

How Billy Chemirmir Exploited Senior Living Communities and Killed 22 People

His crimes led to the formation of an advocacy group.

7m read

The Wedding Venue Employee Who Turned Out to Be a Serial Killer

Edward Wayne Edwards killed his foster child and two couples.

7m read

He Looked Like a Caring Nurse’s Aide—But Donald Harvey Was a Prolific Serial Killer

The "Angel of Death" was convicted of murdering 34 patients.

6m read

How Racial Disparities May Have Impacted the 'Freeway Phantom' Case

Six Black girls were killed in the D.C. area during the early 1970s.

6m read

Was Aileen Wuornos’s Girlfriend Tyria Moore the Reason Why She Killed?

Moore was the one person Wuornos couldn’t bear to lose.

5m read

How Familial DNA Helped Solve the Murder of a Teen Girl and Identify a Serial Killer

"Jupiter Joe" Martinez killed 13-year-old Minerliz Soriano in 1999.

6m read

Inside BTK Killer Dennis Rader's Life in Prison

Rader has been serving 10 consecutive life terms since 2005.

4m read

What Is 'Yosemite Killer' Cary Stayner's Life Like Today?

In 1999, Cary Stayner, murdered four women at Yosemite National Park.

5m read

What Happened to Ted Bundy's Daughter, Rosa?

Rosa Bundy is a private figure connected to a notorious killer.

6m read

Why ‘Monster of the Andes’ Pedro Alonso López Only Served 14 Years for 110 Murders

He claimed to have murdered more than 300 young girls between 1978 and 1980.

7m read

What Did Some of America's Most Notorious Criminals Have as a 'Last Meal'?

The last meals of infamous inmates have varied widely.

6m read

Where Is the Golden State Killer Now? Joseph DeAngelo’s Life in Prison

DeAngelo is housed in a unit with lots of isolation.

4m read

What Was Ted Bundy's Execution Like?

All the details of the serial killer's January 1989 execution.

6m read

Ted Bundy's Childhood: From Lonely Boy to Window Peeper to Serial Killer

How the serial killer's youth led to adult crimes.

6m read

What It Was Like Growing Up With Ted Bundy

Edna Cowell Martin reflects on her bond with her serial killer cousin.

7m read

Charles Manson's Children: How Many Did He Have, and Where Are They Now?

Manson’s sons grew up largely disconnected from their father.

5m read

Did Leaded Gasoline Play a Role in Gary Ridgway and Richard Ramirez's Killings?

Growing evidence highlights lead's connection to violent crimes.

5m read

Was Lavinia Fisher America's First Female Serial Killer?

She was executed in February 1820 in front of onlookers.

6m read

What Did Lucy Letby Do? All About the British Nurse's Crimes and Motive

Prosecutors alleged the caretaker got a “thrill” out of killing.

7m read

From Ray and Faye Copeland to Fred and Rosemary West, These Couples Were Truly Partners in Crime

Love turned deadly for the Copelands, the Wests and more.

12m read

Are the Zodiac Killer and the Black Dahlia's Killer the Same Person?

A self-taught codebreaker believes he’s solved two of the most vexing cold cases of the 20th century.

8m read

The ‘Torso Killer’ Was Convicted of 5 Murders. He’s Now Confessed to More Than 20

Richard Cottingham’s latest one closed a 60-year-old cold case.

6m read

A Serial Killer Known As 'The Doodler' Is Likely Still At Large

Victims are still waiting for the Bay Area killer to be apprehended.

6m read

Is Lead to Blame for the Surge of Serial Killers in the 1970s and ‘80s?

Serial killers Ted Bundy and Gary Ridgway were exposed to lead as kids.

7m read

Who Is 'TiKTok Killer' José Jurado Montilla?

Esther Estepa was pictured with Spanish content creator before she vanished.

4m read

How Serial Killer Andrew Cunanan Evaded Capture Before Murdering Gianni Versace

Cunanan fatally shot the fashion designer on July 15, 1997.

6m read

The Real Killers Who Inspired Hollywood’s Darkest Characters, Like Patrick Bateman and Buffalo Bill

'American Psycho,' 'The Cell' and more draw on actual murders.

8m read

How DNA Solved the Yogurt Shop Murders

Why it took decades to implicate Robert Eugene Brashers.

5m read

How the 1970s Gave Rise to the American ‘Serial Killer’ Trope

John Wayne Gacy and Ted Bundy helped inspire the term.

7m read

Heather Robinson Was Abducted by Her Uncle Who Killed Her Mom

John Edward Robinson sold her as an infant to his brother.

7m read

Richard Ramirez, Dennis Rader and Other Serial Killers Caught in Unexpected Ways

Some unlikely clues took down the most careful murderers.

7m read

Did 'Son of Sam' David Berkowitz Blame a Dog for His Crimes?

The killer is infamous for the explanation behind his attacks.

5m read

Does Aileen Wuornos Haunt the Florida Bar Where She Was Arrested 35 Years Ago?

Police took the serial killer into custody at The Last Resort.

6m read

Officials Have Identified a Serial Killer in Massachusetts

Prosecutors believe Kevin Lino murdered two unhoused men.

5m read

Aileen Wuornos: Did America's First Female Serial Killer Act in Self-Defense?

Wuornos sold sex to survive—ultimately killing seven men.

8m read

4 Female Serial Killers Who Will Haunt Your Dreams

Meet four female murders whose stories you won't forget.

5m read

Albert Fish Abducted Children, Ate Their Remains and Then Confessed in Letters to His Victims' Parents

He was caught after the 1928 murder of 10-year-old Grace Budd.

6m read

The Golden State Killer and Other Serial Killers Who Mysteriously Stopped Murdering

The Golden State Killer and the Zodiac Killer top the list.

6m read

Why There Are Fewer Female Serial Killers Than Male Killers in the U.S.

Female killers' motives also tend to differ from those of males.

7m read

The Golden State Killer Prosecutor Doesn't Think Joseph DeAngelo Stopped Killing in 1986

Thien Ho sentenced Joseph DeAngelo decades after his first kill.

6m read

Aileen Wuornos: Movies, Books and Podcast Episodes About America's First Female Serial Killer

What to watch, read and listen to for more on the female killer.

6m read

The Surprising Way in Which 'Taxi Driver' Influenced 'Son of Sam' David Berkowitz

The killer drew inspiration from the Martin Scorsese movie.

6m read

What Happened to Béla Kiss, Hungary’s Forgotten Serial Killer?

Investigators found bodies of women he killed in barrels in 1916.

6m read

The Real Killers Who Inspired 'The Silence of the Lambs'

Buffalo Bill is based on a combination of actual murderers.

5m read

The ‘Son of Sam’ Law Was Put into Place to Stop David Berkowitz From Profiting Off His Crimes

States aimed to balance free speech with victim compensation.

7m read

Was a Bad Childhood to Blame for 'Night Stalker' Richard Ramirez Becoming a Serial Killer?

A&E talks with Dr. Scott Bonn, criminologist and author of the book, 'Why We Love Serial Killers' about what he thinks were the powerful catalysts for the makings of a serial killer.

5m read

Richard Ramirez and Other Serial Killers Whose Family Members Were Murdered

Some of the most infamous criminals in history experienced murders first-hand before they starting doing the killing themselves.

5m read

Richard Ramirez's Death: What Were the Final Days of the 'Night Stalker' Like?

He was sentenced to death in 1989 for 13 murders, but escaped execution when he died of natural causes in 2013.

5m read

Ed Gein: The Skin-Suit-Wearing Serial Killer Who Inspired Psycho's Norman Bates

Nicknamed "The Butcher of Plainfield," Gein enjoyed robbing graves and amassed a collection of body parts that he put on display at home.

4m read

Serial Killer Ed Gein Was a 'Model Patient' After Being Incarcerated for His Gruesome Crimes

Why the serial killer was so well-behaved after being locked up.

5m read

Why Did 'BTK Killer' Dennis Rader Keep Photographic Evidence of His Crimes?

The serial killer murdered 10 people between 1974 and 1991.

6m read

'BTK Killer' Dennis Rader Blamed 'Factor X' for His Urge to Kill—What Is It?

Identifying what Rader says drove him to kill at least 10 people.

7m read

Did Ed Gein Date Bernice Worden Before Killing Her?

The hardware store owner's murder led to Gein's arrest in 1957.

4m read

Did Ed Gein Help With the Ted Bundy Investigation?

A new wave of storytelling suggests a crossover between the two.

4m read

Ed Gein's Childhood: 'The Butcher of Plainfield' Fixated on His Domineering Mother

Gein's upbringing might have influenced his gruesome behavior.

6m read

Jerry Brudos, the 'Shoe Fetish Slayer,' Stole His Female Victims' Footwear After Killing Them

Brudos was known as the 'Lust Killer' for his Oregon murders.

5m read

John Wayne Gacy's Childhood: 'Killer Clown' Serial Killer Was Victim of Abuse

He murdered 33 male victims, some as young as 15 years old.

6m read

The Hunt to Find John Wayne Gacy's Unidentified Victims

Police are working to ID five of the serial killer's 33 victims.

7m read

John Wayne Gacy's Victims: Gone, But Not Forgotten

Victims of the "Killer Clown" shared some surprising connections.

8m read

Did Ed Gein Kill His Brother? All About Henry Gein’s Suspicious Death

The Butcher of Plainfield's sibling died in a fire in 1944.

5m read

John Wayne Gacy’s Capture Happened Because of a Missing Teen Case

The "Killer Clown" murdered 33 young men and boys in the 1970s.

5m read

How John Wayne Gacy Influenced a Cultural Fear of Clowns

The "Killer Clown" killed at least 33 young men and boys.

6m read

Living with Evil: The Women Who Married John Wayne Gacy

Gacy's outward charm fooled friends and family alike.

6m read

What Was John Wayne Gacy's Murder Trial Like?

Gacy's mental state at the time of his crimes was questioned.

6m read

John Wayne Gacy's Execution: What Were the Serial Killer's Final Days Like?

The "Killer Clown" died via lethal injection in 1994.

6m read

Ed Gein: Movies, Shows, Books and Podcast Episodes About the Butcher of Plainfield

What to watch, read and listen to for more of his ghastly crimes.

7m read

John Wayne Gacy: Movies, Shows, Books and Podcast Episodes About the 'Killer Clown'

What to watch, read and listen to for more of the "Killer Clown."

5m read

How Serial Killer Danny Rolling Influenced 'Scream' with His 1990 Slayings

The "Gainesville Ripper" killed five collegians in three days.

6m read

John Wayne Gacy’s Confession: How the Truth Finally Emerged

The "Killer Clown" revealed the crimes he’d hidden for years.

6m read

Why Do Some Serial Killers Stop Killing? It Might Be Hormonal

Could a decline in testosterone really put a halt to a killer's murderous spree?

5m read

David Berkowitz Confessed to Being the 'Son of Sam.' But Did He Really Act Alone?

During the 1970s, David Berkowitz, also known as 'The Son of Sam,' prowled New York City, fatally shooting couples in cars. By the time he was arrested in August 1977, he had killed six people and wounded seven others. Although the murders stopped after his arrest, several people who worked on the Son of Sam case are convinced Berkowitz didn't act alone.

5m read

About the author

Adam Janos

Adam Janos is a New York City-based writer and reporter. In addition to his work with A&E Crime + Investigation, he is also the lead writer for Hack New York. He holds an MFA in Creative Writing from Rutgers University and is currently developing a one-man show.

More by Author

Fact Check

We strive for accuracy and fairness. But if you see something that doesn't look right, click here to contact us! A&E reviews and updates its content regularly to ensure it is complete and accurate.

Citation Information

Article Title
Charles Cullen, Niels Högel and Others: Inside the Minds of Serial Killers Who Worked in Health Care
Website Name
A&E
Date Accessed
August 20, 2026
Publisher
A&E Television Networks
Last Updated
July 16, 2026
Original Published Date
November 01, 2022
Advertisement
Advertisement
Advertisement