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Barbara has been a hoarder her entire life. The daughter of a dumpster-diver, Barbara's hoarding spiraled out of control after the deaths of her two sons, one to cancer and the other to a gun accident. Richard used to be the ma tre d' at fancy restaurants, but his life went downhill when he developed a compulsion for the clearance sale items which now fill his entire home.

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Mary's obsession includes hoarding cats, and her friends and family have no idea about the horror that awaits them when they walk through her door. Annie cleans houses for a living, but unbelievably is a hoarder in her own home, where she lives with her son, who grew up in the hoard and doesn't know any other kind of life, and her husband, who has Parkinson's disease and cannot get through the clutter.

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Chickens roam all over Constance's property, where she runs a "fresh egg" operation. But some eggs aren't refrigerated, some are growing into embryos, and some just stink up the air. Constance is a food hoarder, and unless she gets help, her daughter will contact the authorities. Jeri Jo is married to a convicted murderer who's in jail for life, and she claims her loneliness causes her to hoard. But now her family has reached the boiling point, and her brother-in-law is threatening to have her removed from her home.

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Debra has filled her house with an avalanche of clothes and run up a $50,000 credit card debt. Fed up, her husband and children are threatening to leave her to wallow in the hoard by herself. Meanwhile, Patty has stuffed her house with so many floor-to-ceiling cardboard boxes that she's had to move to her son's apartment. But now she's filling up that place, too, and the situation has already forced her son's partner to say, "Keep the heap - I'm leaving!"

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Joni's hoarding drove her two sons to turn to drugs to cope, and it forced Child Protective Services to take her granddaughter away from her. She has one last chance to stop the vicious cycle of loss she has inflicted on her family. Millie has agreed to more than one clean-up, only to relapse and start hoarding again. Now her daughter, Chelsea, has given Millie one last ultimatum - "Clean up or lose me forever."

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Manuel was living in his hoarded house with his four grandchildren, ages 5, 6, 7, and 9. They are the love of his life, but they were removed by Child Protective Services and Manuel won t get them back unless he cleans his act up. Meanwhile, Carla has had three failed marriages to men who cheated on her. As if to represent each husband, Carla has hoarded out three homes. Her family is trying to get her to at least clean out one of the houses so she can make a new start in life.