In Cincinnati, detectives Kurt Ballman and Jeff Schare investigate the murder of a 17-year-old boy who had been shot in the head while he was sleeping.
New Orleans Detective Ryan Vaught investigates a gruesome and horrific murder: a grandmother and her four-year-old grandson shot in her bedroom, leaving the grandmother dead and the four-year-old struggling to survive.
In Tucson, a young man is found shot to death on the street. And in Memphis, Sergeant Debo Carson investigates the brutal murder of a woman whose body was found dumped on the railroad tracks.
In Birmingham, Detective Chris Anderson returns to his childhood neighborhood to investigate the murder of a man killed over ten pounds of marijuana.